Seed healthcare VCs US: who writes first checks in 2026

Multi-stage generalist with deepest bets in AI, crypto, bio, and American dynamism; writes seed through late-stage checks and runs in-house platform teams.

The original arch-tier fund; runs seed scouts, Arc accelerator, and a permanent-capital structure that deploys across stages and decades.

Seed-stage digital health and bio

General Catalyst is a global investment and transformation company that partners with ambitious entrepreneurs to build resilient companies. It is powered by early-stage venture capital and invests from seed through growth and later stages, with a broad focus that includes AI, hea

Khosla Ventures is a venture capital firm founded by Vinod Khosla and based in Menlo Park, California. It backs early-stage companies and separates its investing between a Seed Fund and a growth-oriented Opportunity Fund. The firm focuses on science and business innovation across

Lightspeed Venture Partners is a global multi-stage venture capital firm backing bold founders and disruptive innovations from Seed through Series F, with a long track record in category-defining technology companies. Its investment focus spans enterprise and B2B software, consum

Pear VC is a Menlo Park-based venture firm founded by Mar Hershenson and Pejman Nozad in 2014 and positioned as a specialist in pre-seed and seed investing. It leads and co-leads seed-stage investments and supports founders with hands-on help across recruiting, sales, marketing,

Healthcare AI from seed to Series A